On account of their abundance, ltr retrotransposons are believed to hold major significance for genome structure and function. Genomic resources for wild populations of the house mouse. Mus musculus definition of mus musculus by the free. When comparing the mouse genomic sequence with that of human, the overall.
Mice are biologically similar to humans and are thus good models for genetic diseases and research on the immune system. Within that directory a readme file will describe the various files available. The mouse mus musculus is the most commonly used mammal in the laboratory. Mus musculus genome medical definition and pronunciation. Mus musculus castaneus extends from central asia c afghanistan south of hindu kush, pakistan, peninsular and ne india, e and c nepal. The mouse genome sequencing consortium is a joint project between the whitehead institutemit center for genome research, the washington university genome sequencing center, the wellcome trust sanger. Receptor for medium and longchain free fatty acids ffas. The house mouse mus musculus has a longstanding history as a. Involved in cell mobility and transcription regulation through proteinprotein interactions. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. It utilizes the foodstuffs and domiciles of man, as a result of which it has. In brief, reads were mapped against the mouse mm10 genome reference sequence.
Download a free trial for realtime bandwidth monitoring, alerting, and more. Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Trem1 triggering receptor expressed on myeloid cells 1. The complete mouse reference genome was sequenced in 2002. G proteincoupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids scfas, and that plays a role in the regulation of wholebody energy homeostasis and in intestinal immunity. Whole genome sequence of two wildderived mus musculus. The mouse was the second mammal to have its genome sequenced. It has become a frequently used model for understanding human disease and development due to its small size, short lifecycle and rapid breeding cycle. A number of laws, guidelines and policies exist to protect animals, including mice, from unnecessary pain or distress as part of the research process. Mus musculus mouse genome info pathway map brite hierarchy module genome map blast taxonomy. Wild populations of the house mouse mus musculus represent the raw genetic material for the classical inbred strains in biomedical research and are a. When comparing the mouse genomic sequence with that of hu man, the overall.
This use has increased in recent years with the development of techniques to successfully modify the mouse genome. Proteome characterization of used nesting material and. Pmid 31263278, free pmc article inhibition of trem1 reduces inflammation and oxidative stress after spinal cord injury sci associated with ho1 expressions. Candidate insulin dependent diabetes regions on chromosomes 1, 3, 4, 6, 11 and 17 have been annotated in both the cl57bl6j reference strain and one or more of nodmrktac, nodshiltj and 129 strains. Ffar4 free fatty acid receptor 4 mus musculus mouse. Ffar2 free fatty acid receptor 2 mus musculus mouse. This small rodent probably has a world distribution more extensive than any mammal, apart from humans. This assembly is used by ucsc to create their mm9 database. We would like to show you a description here but the site wont allow us.
Peripheral trem1 responses to brain and intestinal immunogens amplify stroke severity. A set of centrallymaintained and updated scientific databases is made available to users of helix and biowulf. The mouse genome sequencing consortium is a joint project between the whitehead institutemit center for genome research, the washington university genome sequencing center. Genome patterns of selection and introgression of haplotypes in natural populations of the house mouse mus musculus fabian staubach1,2, anna lorenc1, philipp w. Browse the list download sequence and annotation from refseq or genbank. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response.
Mus musculus article about mus musculus by the free. The mitochondrial genome and most of the nuclear genome of classical laboratory inbred strains of m. Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cellfate specification, progenitorcell proliferation and the control of asymmetric cell division, in many different species and organs. For more information about this assembly, see grcm38 in the ncbi assembly database. It is particularly good at aligning reads of about 50 up to 100s or 1,000s of characters, and particularly good at aligning to relatively long e. Wildderived inbred strains are available from mus musculus domesticus, mus musculus musculus, mus musculus molossinus, mus musculus castaneus, mus spretus, and mus spicilegus. Hybrids between mice of the mus musculus complex are viable and most are also. Click on a link below to see the available databases. The house mouse mus musculus is a small mammal of the order rodentia, characteristically having a pointed snout, large rounded ears, and a long and hairy tail. Long terminal repeat retrotransposons of mus musculus. A genome position can be specified by the accession number of a sequenced genomic region, an mrna or est, a chromosomal coordinate range, or keywords from the genbank description of an mrna. Data taken from the database must not be reproduced in published lists, online databases, or other such formats, nor redistributed without.
These reference sequences exist independently of genome builds. More information and statistics download dna sequence fasta. Acts as a receptor for omega3 fatty acids and mediates robust antiinflammatory effects, particularly in macrophages and fat cells. Mus musculus synonyms, mus musculus pronunciation, mus musculus translation, english dictionary definition of mus musculus. It is one of the most abundant species of the genus mus. Genomic resources for wild populations of the house mouse, mus. The four main types of proteoglycans include hyaluronan ha, which does not occur as a pg but in free form, heparan sulfate proteoglycans hspgs, chondroitin sulfate proteoglycans cspgs, dematan sulfate proteoglycans dspg and keratan sulfate proteoglycans kspgs br. They comprise about 8% of the human genome and approximately 10% of the mouse genome.
Recent advances in genome sequencing of a variety of. Mus musculus house mouse the mouse is one of the most useful models for comparison to humans as it is also a mammal. As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. The analysis we present is a comprehensive, genomewide analysis of cnvs in mus musculus, which increases the number of known variants in the species and will accelerate the identification of novel variants in future studies. Interaction between app molecules on neighboring cells promotes synaptogenesis.
In 2003, the first sequenced mouse genome was that of the c57bl6 abbreviated b6 mouse inbred strain, and since then 17 additional mouse inbred strains have been. A genome position can be specified by the accession number of a sequenced genomic region, an mrna or est, a. Cx26 partial loss causes accelerated presbycusis by redox imbalance and dysregulation of nfr2 pathway. The house mouse is distributed almost throughout the world, except the arctic and antarctic. As the cost of genomescale sequencing continues to decrease and new technologies for genome editing become widely adopted, the laboratory mouse is more important than ever as a model system for understanding the biological significance of human genetic variation and for advancing the basic research needed to support the emergence of genome. Mus musculus castaneus an overview sciencedirect topics. The house mouse mus musculus is a small mammal of the order rodentia, characteristically having. These two inbred strains were selected based on their geographic origin, karyotype, and use in. This is a rather conservative filter on snp quality, but users are free. The house mouse mus musculus is a common rodent that is distributed throughout the world.
Can promote transcription activation through binding to. Click the track search button to find genome browser tracks that match specific selection criteria. This largescale collaborative project, mainly based on the free, willing. Long terminal repeat ltr retrotransposons make up a large fraction of the typical mammalian genome. In many cases, the sequence data is segregated into directories for each chromosome. Bandwidth analyzer pack analyzes hopbyhop performance onpremise, in hybrid networks, and in the cloud, and can help identify excessive bandwidth utilization or unexpected application traffic. Gjb2 gap junction protein, beta 2 mus musculus house. The authors here unravel a novel role of cardiac myoglobin in governing fatty acid metabolism to ensure the physiological energy production through betaoxidation, preventing myocardial lipid accumulation and preserving cardiac functions. The mouse genome was sequenced in 2002 and it was shown that almost every gene in the mouse genome had a human homolog. You can easily download the latest protein sequences for mus musculus proteome here. The antiinflammatory effects involve inhibition of tak1 through a betaarrestin 2 arrb2tab1dependent effect, but independent of the gqg11coupled pathway.
The source for the genome browser, blat, liftover and other utilities is free for nonprofit academic research and for personal use. Download the complete genome for an organism ncbi nih. In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers. Its geographic spread has been facilitated by its commensal relationship with man which extends back at least 8,000 years. House mouse mus musculus, a mammal of the family muridae of the order rodentia. Here, we report the wholegenome sequencing of two wildderived mouse inbred strains, leweseij and zalendeeij, of mus musculus domesticus origin. Although a wild animal, the house mouse has benefited significantly from associating with human habitation to the point that truly wild populations are significantly less common. Wildderived mouse inbred strains are becoming increasingly popular for complex traits analysis, evolutionary studies, and systems genetics. The july 2007 mouse mus musculus genome data were obtained from the build 37 assembly by ncbi and the mouse genome sequencing consortium. Mus musculus brownishgrey old world mouse now a common household pest worldwide house mouse mouse any of numerous small rodents typically.
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